Intrathecal
Baclofen: Successful Outcomes
RESULTS INCLUDE:
- Reduction
in pain
- Increased
comfort
- Improved
self-care
- Improved
skin integrity
- Greatly
reduced muscle tone
- Long-term
reduction of spasticity
- Improved
self-care & independence
- Improvements
in sleep and cognition
- Improved
control of bladder & bowel regimen
- Greatly
reduced frequency of spasms & clonus
- Improvement
in bladder continence, function & volume
- Decrease
in chronic, intolerable side effects of spasticity
- Improvement
in quality of life for patient and caregiver: with improved self-esteem;
improved transfers, dressing, feeding, hygiene, catheterization,
walking, mobility, gait patterning, stair climbing, writing,
sitting, sleep, cognition
Intrathecal
Baclofen: Patient Benefits
- Decreased
spasticity results in decreased pain, improvement in activities
of daily living (ADL), advancement in the performance of bowel
and bladder programs, and improved quality of sleep.
- Compared
to oral therapies, ITB markedly reduces intolerable side effects
of spasticity and medication ( such as feeling drugged, mentally
sluggish, and impaired memory) and in a vast majority eliminates
needs for other spasticity medications or treatments such as
destructive orthopedic procedures or ablative neurosurgical interventions.
- ITB
can be used in conjunction with other therapies.
Intrathecal
Baclofen: BOWEL & BLADDER FUNCTION
Evaluated
in 3 studies
- 18/24
improved bladder management.
- 7/7
improved bladder functionimprovements: increased bladder volume,
change from indwelling catheter management to intermittent catheterizations,
increased continence between catheterizations, decreased urinary
infections.
- 7/7
improved bowel programs.
(Loubser,P.G. etal, "Continuous
Infusion of Intrathecal Baclofen: Long-term Effects on Spasticity
in Spinal Cord Injury, Paraplegia,29:48-64,1991)
RESULTS OF ITB
THERAPY
Outcome
of ITB Therapy in Patients with Spasticity of
Spinal
& Cerebral Origin
Results
of ITB Trials in Patients with Spasticity of Spinal Cord Origin:
- Decreased
lower extremity ashworth scores
- Decreased
spasm score
- Effectiveness
maintained over many years, without long-term need for continually
increasing dosing
Summary
of Effectiveness of ITB in Spinal Spasticity Based on 9 Independent
Studies
|
Total
# of patients |
168 |
|
Spasticity
abolished |
97% |
|
Spasms
abolished |
98% |
|
Bladder
function improved |
78% |
|
Overall
functional improvement |
70% |
Lower
- Extremity Ashworth Scores in Spasticity of Spinal Origin Patients
ashworth
scale score reduction mainted over time
Reduction
of Lower - Extremity Spasm Score in Spasticity of Spinal Origin
spasm
score reduction maintained over time
Post
Market Surveillance Study: Lower Extremity Ashworth Scores In
Spasticity of Spinal Origin Patients - Reduction Over Time With
ITB
ashworth
scale reduction persists over many years
Ashworth
Scale Reduction After ITB - Continued Relief Over Time
ITB
Daily Dose Over Time: Comparison of Spasticity Reduction of Spinal
and Cerebral Origin Patients
Reduction
of Lower Extremity Ashworth Scores During Screening Trial in Spasticity
of Cerebral Origin
reduction
in ashworth scale score versus placebo during test dose trial
Reduction
in Upper Extremity Ashworth Scores in Spasticity of Cerebral Origin
Patients
ashworth
scale reduction in arm over time
(All
the figures above are from Clinical Trials section of Clinical
Experience from the ITB Therapy Product Monograph from Medtronic
1996)
ITB
Results - contined next page
